Table 3. Univariate and multivariable analyses for objective response.

		Objective Response		Univariate analysis			Multivariable analysis (1st step)						Multivariable analysis (2nd step)
				Odds ratio	95%CI	p-value	Β	SE(β)	Z	Odds ratio	95% CI	p-value	β	SE(β)	Z	Odds ratio	95% CI	p-value
2nd step	1st step	Age	<72	0.813	0.288–2.293	0.695
			≥72	1
		Sex	male	0.462	0.142–1.503	0.199
			female	1
		PS	0	0.390	0.118–1.290	0.123
			1-	1
		Etiology	non-viral	1.446	0.493–4.238	0.502
			viral	1
		Child-Pugh	A	0.706	0.136–3.653	0.678
			B	1
		Up to seven	in	0.463	0.129–1.481	0.184
			out	1
		Macrovascular invasion	presence	2.351	0.717–7.713	0.158
			absence	1
		Extra-hepatic spread	presence	3.424	1.183–9.907	0.023	0.967	0.566	1.709	3.247	0.853–8.000	0.087	1.308	0.880	1.487	3.704	0.660–20.833	0.126
			absence	1						1						1
		Baseline AFP	≥400 ng/mL	4.256	1.432–12.644	0.009	1.253	0.572	2.189	3.497	1.140–10.753	0.029
			<400 ng/mL	1						1
		Baseline DCP	≥1,000 mAU/mL	1.372	0.451–4.176	0.577
			<1,000 mAU/mL	1
		Line	1st	1.272	0.443–3.656	0.654
			later	1
		AFP response	responder	5.833	1.658–20.522	0.006							1.796	0.882	2.035	6.023	1.068–33.956	0.042
			non-responder	1												1
		DCP response	responder	8.156	2.220–29.968	0.002							2.456	0.892	2.753	11.657	2.029–66.989	0.006
			non-responder	1												1