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. 2024 Sep 13;18(9):e0012487. doi: 10.1371/journal.pntd.0012487

Fig 3. Anti-T. cruzi antibody reactivity of serum samples from Chagas disease patients at study baseline using distinct target antigens employed for genotype-specific serodiagnosis purpose.

Fig 3

(A) Summary of attribute sets (“antigens/serum dilutions/cut-offs”) used for genotype-specific serodiagnosis of Chagas disease, according to Alessio et al. (2020) [24]. (B) IgG1 reactivity profile of serum samples from Chagas disease patients at Study Baseline (n = 46) to distinct target antigens: epimastigote (EPI) and trypomastigote (TRYPO) from TcI and amastigote (AMA) and trypomastigote (TRYPO) from TcVI T. cruzi DTUs along the titration curve (1:1,000 to 1:32,000). The results are presented in scatter plot distribution of individual values over bars (median) expressed as the percentage of positive fluorescent parasites (PPFP). The set of attributes used for genotype-specific serology of Chagas disease by Chagas-Flow ATE IgG1 are underscored, comprising: “target antigens”, “serum dilution” (dashed rectangles) and “cut-off” (dashed lines).