TABLE 1.
List of the pipeline psychiatric medications in Phase III trials
| DISORDER | NUMBER OF MEDICATIONS | PHASE III MEDICATION |
|---|---|---|
| Schizophrenia | 9 | Brilaroxazine (oxaripiprazole, RP-5063), iclepertin (BI425809), lumateperone (Caplyta), olanzapine subcutaneous (TEV-749), raloxifene (Evista), roluperidone (MIN-101), ulotaront (SEP-363856), vortioxetine (Trintellix), xanomeline + trospium (KarXT) |
| Bipolar disorders | 5 | Amisulpride/esamisulpride (SEP-4199), armodafinil (Nuvigil), brexpiprazole (Rexulti), cycloserine + lurasidone (Cyclurad), lumateperone (Caplyta) |
| Depressive disorders | 25 | Aticaprant (JNJ-67953964), buprenorphine + samidorphan (ALKS 5461), cariprazine (Vraylar), celecoxib (Celebrex), esmethadone (REL-1017), estradiol + progesterone, ezogabine (retigabine), lumateperone (Caplyta), lurasidone (Latuda), minocycline (Minocin, CoreMino [DSC], Minolira, Solodyn, Ximino), mitizodone, NMRA-335140, navacaprant (BTRX-335140, NMRA-140), pimavanserin (Nuplazid), pioglitazone + citalopram + chlordiazepoxide, pramipexole (Mirapex), psilocybin (COMP360), racemic ketamine (Wafermine), racemic ketamine subcutaneous, rapastinel (GLYX-13), seltorexant (MIN-202, JNJ-4u2847922), solriamfetol (Sunosi), toludesvenlafaxine (ansofaxine), ulotaront (SEP-363856), zuranolone (Zurzuvae) |
| Anxiety disorders | 11 | ABIO-08/01, agomelatine (Valdoxan, Thymanax), amibegron (SR58611A), buagafuran, fasedienol (Aloradine, PH94B), pregabalin (Lyrica), quetiapine (Seroquel), toludesvenlafaxine (ansofaxine, LY03005, LPM570065), ulotorant (SEP-363856), vortioxetine (Trintellix) |
| Post-traumatic stress disorder (PTSD) | 5 | Cyclobenzaprine (Flexeril, Amrix), glecaprevir/pibrentasvir (Mavyret), MDMA (3,4-methylenedioxymethamphetamine), prazosin (Minipress), propranolol (Inderal) |
| Obsessive compulsive disorder (OCD) | 1 | Troriluzole |
| Eating disorders | 2 | Naltrexone-bupropion (Contrave), solriamfetol (Sunosi) |
| Sleep-wake disorders | 2 | Mazindol ER (Quilience), sodium oxybate (FT218, Lumryz) |
| Sexual dysfunctions | 3 | Dutasteride-tamsulosin (Jalyn), onabotulinumtoxinA (Botox), sildenafil oral film (CURE film Blue) |
| Substance use disorders | 1 | Baclofen (Lioresal) |
| Neurocognitive disorders | 22 | ACP-204, AR1001, dextromethorphan-bupropion (Auvelity, AXS-05), dapagliflozin (Forxiga), latrepirdine (DMB-I, Dimebon), donanemab, gantenerumab (RO4909832), GV1001, levetiracetam low dose (AGB101, Keppra), masitinib (Masivet), masupirdine, metformin extended release, nabilone (Cesamet), nilotinib (Tasigna), pimavanserin (Nuplazid), remternetug, sabirnetug (ACU193), simufilam (PTI-125), suvorexant (Belsomra), tricaprilin (CER-0001), valiltramiprosate (ALZ-801), xanomeline (Lumeron) |
| Neurodevelopmental disorders (attention deficit hyperactivity disorder) | 3 | Centanafadine (EB-1020), NRCT-101SR, soliriamfol (Sunosi) |