Table 2. Rates of Positive Pathogenic Variants by Indication.

Variable	Total	Pathogenic/likely pathogenic mutations
		All variants		BRCA1/2		Non-BRCA1/2
		n (%)	P-value	n (%)	P-value	n (%)	P-value
Age at diagnosis (years)			0.18		0.23		0.29
≤ 70	102	9 (8.8%)		3 (2.9%)		6 (5.8%)
> 70	102	13 (12.7%)		5 (4.9%)		8 (7.8%)
Triple-negative disease			0.37		0.24		0.33
Yes	33	3 (9.1%)		2 (6.1%)		1 (3.0%)
No	171	19 (11.1%)		11 (6.4%)		8 (4.7 %)
≥ close blood relative with breast cancer diagnosed at age ≤ 50 years			0.47		0.17		0.21
Yes	110	12 (10.9%)		3 (2.7%)		9 (8.2%)
No	94	10 (10.6%)		5 (5.3%)		5 (5.3%)
≥ 1 close blood relative with: Epithelial ovarian cancer at any age; Exocrine pancreatic cancer at any age; Metastatic prostate cancer at any age			0.18		0.24		0.29
Yes	33	5 (15.2%)		2 (6.1%)		3 (9.1%)
No	171	17 (9.9%)		6 (3.5%)		11 (6.4%)
≥ 2 close relatives with breast cancer diagnosed at any age			0.38		0.39		0.27
Yes	86	10 (11.6%)		3 (3.5%)		7 (8.1%)
No	118	12 (10.2%)		5 (4.2%)		7 (5.9%)
More than one primary breast cancers, first diagnosed before age of 65 years			0.36		0.23		0.45
Yes	13	1 (7.7%)		0		1 (7.7%)
No	191	21 (10.9%)		8 (4.2%)		13 (6.8%)
Diagnosed at any age with a close male relative with breast cancer at any age			0.24		0.34		0.29
Yes	4	0		0		0
No	200	22 (11%)		8 (4%)		14 (7%)
All patients	204	22 (10.8%)		8 (3.9%)		14 (6.9%)