Table 3.

(a) Mesures of diagnostic accuracy according to subgroup comorbidities
BNP
	Threshold	Sens	Spec	PPV	NPV	Accuracy	AUC	P value
BNP	256 [234; 276]	0.82 [0.79–0.85]	0.7 [0.67–0.74]	0.82 [0.81–0.84]	0.7 [0.67–0.73]	0.77 [0.76–0.79]	0.83 [0.81–0.84]
75–85	236 [176; 280]	0.81 [0.76–0.87]	0.75 [0.67–0.8]	0.83 [0.8–0.85]	0.72 [0.69–0.79]	0.78 [0.77–0.81]	0.84 [0.82–0.86]	0.015
>85	262 [236; 442]	0.84 [0.67–0.87]	0.63 [0.59–0.8]	0.81 [0.8–0.87]	0.68 [0.56–0.71]	0.77 [0.71–0.79]	0.81 [0.78–0.83]
eGFR < 30	446 [341; 568]	0.76 [0.69–0.86]	0.66 [0.55–0.77]	0.87 [0.84–0.9]	0.48 [0.43–0.58]	0.74 [0.69–0.79]	0.76 [0.71–0.81]	<0.01
eGFR ≥ 30	254 [230; 270]	0.81 [0.78–0.83]	0.72 [0.7–0.77]	0.82 [0.8–0.84]	0.72 [0.68–0.74]	0.78 [0.76–0.79]	0.83 [0.82–0.85]
eGFR < 45	358 [222; 468]	0.7 [0.68–0.91]	0.71 [0.49–0.76]	0.88 [0.84–0.9]	0.45 [0.43–0.66]	0.7 [0.69–0.81]	0.78 [0.75–0.81]	<0.01
eGFR ≥ 45	236 [215; 262]	0.78 [0.75–0.81]	0.75 [0.72–0.79]	0.8 [0.78–0.82]	0.74 [0.71–0.77]	0.77 [0.75–0.79]	0.83 [0.81–0.85]
eGFR < 60	270 [248; 455]	0.84 [0.67–0.88]	0.62 [0.57–0.79]	0.84 [0.83–0.89]	0.62 [0.5–0.67]	0.78 [0.7–0.8]	0.8 [0.78–0.83]	0.155
eGFR ≥ 60	236 [152; 274]	0.75 [0.71–0.88]	0.78 [0.65–0.82]	0.78 [0.72–0.81]	0.75 [0.73–0.83]	0.77 [0.75–0.79]	0.83 [0.8–0.85]
BMI < 30	310 [224; 380]	0.81 [0.76–0.9]	0.79 [0.68–0.84]	0.87 [0.83–0.89]	0.7 [0.67–0.81]	0.8 [0.78–0.84]	0.87 [0.84–0.9]	0.036
BMI ≥ 30	184 [172; 206]	0.79 [0.74–0.88]	0.77 [0.64–0.89]	0.9 [0.86–0.95]	0.59 [0.51–0.7]	0.79 [0.74–0.85]	0.78 [0.7–0.86]
No AF	254 [222; 272]	0.82 [0.79–0.86]	0.76 [0.72–0.79]	0.78 [0.75–0.8]	0.8 [0.78–0.83]	0.79 [0.77–0.81]	0.85 [0.83–0.87]	<0.01
AF	302 [247; 438]	0.76 [0.62–0.83]	0.62 [0.54–0.75]	0.87 [0.86–0.9]	0.44 [0.37–0.5]	0.73 [0.65–0.77]	0.75 [0.72–0.78]
W	236 [198; 268]	0.82 [0.78–0.85]	0.68 [0.63–0.73]	0.82 [0.81–0.84]	0.67 [0.63–0.71]	0.77 [0.75–0.79]	0.81 [0.78–0.83]	<0.01
M	274 [234; 358]	0.84 [0.74–0.87]	0.72 [0.68–0.82]	0.82 [0.8–0.86]	0.74 [0.67–0.79]	0.79 [0.76–0.81]	0.86 [0.84–0.88]

(b)
NT‐proBNP
	Threshold	Sens	Spec	PPV	NPV	Accuracy	AUC	P value
NT‐proBNP	1748 [1670; 2015]	0.84 [0.8–0.85]	0.67 [0.66–0.73]	0.84 [0.84–0.86]	0.68 [0.63–0.69]	0.79 [0.77–0.8]	0.81 [0.8–0.82]
75–85	1680 [1387; 1760]	0.82 [0.8–0.85]	0.75 [0.71–0.77]	0.86 [0.84–0.87]	0.69 [0.67–0.72]	0.79 [0.78–0.8]	0.84 [0.83–0.85]	<0.01
>85	2235 [1751; 2772]	0.79 [0.77–0.87]	0.65 [0.57–0.68]	0.84 [0.83–0.86]	0.56 [0.55–0.65]	0.75 [0.74–0.79]	0.77 [0.75–0.79]
eGFR < 30	3474 [1840; 5286]	0.79 [0.68–0.92]	0.51 [0.36–0.62]	0.9 [0.89–0.92]	0.3 [0.25–0.47]	0.75 [0.68–0.84]	0.68 [0.64–0.72]	<0.01
eGFR ≥ 30	1682 [1552; 1980]	0.82 [0.78–0.84]	0.7 [0.68–0.74]	0.83 [0.82–0.84]	0.69 [0.66–0.71]	0.78 [0.77–0.79]	0.82 [0.81–0.83]
eGFR < 45	2437 [1972; 2798]	0.85 [0.78–0.88]	0.51 [0.47–0.59]	0.88 [0.87–0.89]	0.44 [0.38–0.49]	0.79 [0.74–0.81]	0.72 [0.7–0.74]	<0.01
eGFR ≥ 45	1593 [1292; 1757]	0.78 [0.77–0.84]	0.75 [0.69–0.77]	0.81 [0.78–0.82]	0.72 [0.71–0.77]	0.77 [0.76–0.78]	0.83 [0.82–0.84]
eGFR < 60	2010 [1708; 2411]	0.85 [0.8–0.88]	0.56 [0.52–0.62]	0.87 [0.86–0.88]	0.51 [0.46–0.56]	0.78 [0.75–0.81]	0.75 [0.73–0.76]	<0.01
eGFR ≥ 60	1553 [1183; 1698]	0.76 [0.74–0.83]	0.78 [0.71–0.8]	0.76 [0.73–0.78]	0.77 [0.76–0.82]	0.77 [0.76–0.78]	0.83 [0.82–0.85]
BMI < 30	1995 [1410; 2260]	0.85 [0.81–0.9]	0.72 [0.66–0.77]	0.83 [0.81–0.85]	0.74 [0.7–0.81]	0.8 [0.78–0.82]	0.83 [0.81–0.85]	0.227
BMI ≥ 30	1375 [777; 2178]	0.79 [0.66–0.91]	0.69 [0.56–0.84]	0.85 [0.82–0.91]	0.61 [0.52–0.77]	0.76 [0.7–0.82]	0.8 [0.76–0.84]
No AF	1738 [1664; 1984]	0.8 [0.76–0.81]	0.74 [0.72–0.78]	0.77 [0.76–0.79]	0.77 [0.74–0.78]	0.77 [0.76–0.78]	0.83 [0.82–0.84]	<0.01
AF	2332 [2008; 2743]	0.78 [0.74–0.85]	0.57 [0.5–0.62]	0.9 [0.9–0.91]	0.33 [0.31–0.38]	0.75 [0.72–0.79]	0.71 [0.69–0.73]
W	1698 [1565; 2100]	0.84 [0.77–0.86]	0.66 [0.63–0.72]	0.84 [0.83–0.86]	0.66 [0.6–0.69]	0.78 [0.75–0.79]	0.8 [0.78–0.81]	<0.01
M	1800 [1669; 2157]	0.84 [0.8–0.86]	0.7 [0.68–0.76]	0.85 [0.84–0.87]	0.7 [0.65–0.72]	0.8 [0.78–0.81]	0.83 [0.82–0.84]

AF, atrial fibrillation; BMI, body mass index; eGFR, estimate glomerular filtration rate, W, women; M, Men.