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Natural and artificial EGFR ligands. Shown at the top is native epidermal growth factor (pEGF) followed by the different EGF molecules used in this study. TM includes the transmembrane and juxtamembrane regions, whereas the membrane-anchoring domain includes both the TM region and the cytoplasmic domain. Note that EGF-hcF and EGF-hc contain the membrane-anchoring domain of HB-EGF (shown at the bottom) but have the same receptor-binding core and signal sequence of EGF-ctF.
