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. 2024 Sep 12;18:1448365. doi: 10.3389/fnins.2024.1448365

Figure 5.

Figure 5

Current-driven responses in layer 4 of a brain slice under the glutamatergic receptor antagonist/agonist condition. (A) Under 10-μM D-AP5 application, LFP responses were recorded in layer 4 before and after TS. Three LFP responses are illustrated (i) before (black trace), (ii) 20 min (red trace), and (iii) 60 min after TS (blue trace) applied to layer 4 in (a). The test stimuli were repetitively applied to layer 4. Time course of negative-going peak magnitude is illustrated during the whole recording period (70 min) in (b). (B) Similarly, under 50-μM DNQX application, LFP responses were recorded in layer 4 before and after TS. Three LFP responses are illustrated (i) before (black trace), (ii) 20 min (red trace), and (iii) 60 min after TS (blue trace) applied to layer 4 in (a). Time course of negative-going peak amplitudes is illustrated during the whole recording period (70 min) in (b). (C) Under 50-μM MPEP application, LFP responses were recorded in layer 4 before and after TS. Three LFP responses are illustrated (i) before (black trace), (ii) 20 min (red trace), and (iii) 60 min after TS (blue trace) applied to layer 4 in (a). The test stimuli were repetitively applied to layer 4. Time course of negative-going peak amplitudes is illustrated during the whole recording period (70 min) in (b). TS was applied at time 0 min in the plot (indicated by a dashed line and an arrow). The timings of a test stimulus are indicated by the inverted triangles in (a).