Extended Data Fig. 7. Assessing neurodegeneration in demyelination and in Myrf cKO mice.

(A) Immunostaining for neurofilament H (NF-H), myelin basic protein (MBP), and neurofilament light chain DegenoTag (NF-Degen) in spinal cords of control mice and mice that underwent experimental autoimmune encephalitis (EAE). Disordered NF-H and prominent NF-Degen signal can be detected in the spinal cord of EAE mice, most notably in regions of demyelination. (B) Immunostaining for NF-H, MBP, and NF-Degen in visual cortex of control and Myrf cKO mice.