Extended Data Fig. 4. Analysis of Caspr+ paranodes in adult visual cortex of control and Myrf cKO mice.
(A) Example images of myelin sheaths (MBP) and paranodes (Caspr) in adult visual cortex. (B) Example images of pairs of Caspr+ puncta categorized as a node (top row) or as heminodes (bottom row). (C) Quantification of number of nodes (p = 0.0004) and (D) heminodes (p = 0.0001) by genotype. Panels C-D: unpaired two-tailed t-tests, n = 4 CTL mice and 6 cKO mice. Data are presented as mean +/- SEM. ***p < 0.001, ns = not significant. Additional statistical details in Table S1.