Figure 1.

2ME2 inhibits breast cancer cell proliferation and metastasis. (A) Cell viability of MDA-MB-468, MDA-MB-231 and MCF-10A cells treated with 1-20μM of 2ME2 for 24, 48 and 72h. (B, C) Expression level of proliferative markers in MDA-MB-468 cells at different time points of treatment with 5μM of 2ME2. (D, E) Effect of 2ME2 on migratory capacity of MDA-MB-468 cells. (F, G) Effect of 2ME2 on invasive ability of MDA-MB-468 cells. (H, I) Colony formation ability of MDA-MB-468 cells with 2ME2 treatment. (J) Expression level of EMT markers in 2ME2 treated MDA-MB-468 cells at different time points. *P < 0.05.