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. 2024 Sep 12;14:1371792. doi: 10.3389/fonc.2024.1371792

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Copyright © 2024 Subramani, Chatterjee, Pedroza, Poudel, Rajkumar, Annabi, Penner and Lakshmanaswamy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2ME2 induces cell cycle arrest and Apoptosis. (A, B) Cell cycle analysis of 2ME2 treated MDA-MB-468 cells. (C, D) Cell cycle regulators were assessed in 2ME2 treated MDA-MB-468 cells at 24, 48 and 72h using Western blot and densitometric analysis. (E) Apoptosis analysis of 2ME2 treated MDA-MB-468 cells at various time points, (F) Graphical representation of percentage apoptosis/cell death in 2ME2 treated MDA-MB-468 cells. (G, H) Expression levels and densitometric analysis of pro and anti-apoptotic markers in 2ME2 treated MDA-MB-468 cells at different time points. *P < 0.05.