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. 2024 Sep 12;14:1371792. doi: 10.3389/fonc.2024.1371792

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Copyright © 2024 Subramani, Chatterjee, Pedroza, Poudel, Rajkumar, Annabi, Penner and Lakshmanaswamy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA target genes altered by 2ME2 treatment are amplified in breast cancer patients. (A, B) Five target genes of up-regulated miRNA in 2ME2 treatment, (A) Oncoprint represents genetic alterations such as inframe mutations (putative driver and unknown significance), missense mutation (putative driver and unknown significance), amplification and deep deletion of breast cancer tumor samples. (B) KMPlot analysis shows cumulatively breast cancer patient samples that have high expression of miRNA target genes that are associated with overall survival. (C, D) Eight target gene of down-regulated miRNA in 2ME2 treatment, (C) Oncoprint represents genetic alterations such as inframe mutations (putative driver and unknown significance), missense mutation (putative driver and unknown significance), amplification and deep deletion of breast cancer tumor samples. (D) KMPlot analysis shows cumulatively breast cancer patient samples that have altered expression of miRNA target genes that are associated with overall survival. In KMPlot, unaltered means that there were no gene alterations in the queried genes within the selected profile of 2ME2 treated samples. Altered means that there was at least one gene altered in the queried genes within the selected profile of 2ME2 treated samples.