TABLE 1.
Inhibitor drugs targeting UPS and DUBs for cancer treatment.
| UPS and DUBs | Anticancer drugs/inhibitor | References |
|---|---|---|
| Proteasome | Bortezomib, curcumin, b‐AP15 | 217 , 218 , 219 , 220 , 221 , 222 , 223 |
| Ubiquitin proteasome system | Piperlongumine, curcusone D | 220 , 223 |
| USP1 | ML323, SJB2‐043, SJB3‐019A, GW7647, pimozide, rottlerin | 224 , 225 , 226 |
| USP2 | ML364, LCAHA, 6TG | 227 , 228 |
| USP4 | Vialinin A | 229 , 230 |
| USP5 | WP1130, vialinin A | 229 , 230 , 231 , 232 |
| USP7 | FT671, FT827, GNE‐6640, GNE‐6776, compound 1, compound 4, P5091, P22077, HBX41108, HBX19818, Cpd1, Cpd2, Cpd8 | 231 , 233 , 234 , 235 , 236 , 237 , 238 , 239 |
| USP8 | DUBs‐IN‐2, MB7295 | 240 |
| USP9X | WP1130, EOAI3402143 | 233 , 241 |
| USP11 | MIX | 242 |
| USP14 | IU‐1/analogues, b‐AP15, VLX1570, WP1130, auranofin | 233 , 243 , 244 , 245 , 246 |
| USP15 | MIX | 242 |
| USP17 | WP1130 | 233 |
| USP20 | GSK2643943A | 247 |
| USP24 | EOAI3402143 | 241 |
| USP25 | AZ1/2/3/4 | 248 |
| USP28 | AZ1/2/3/4 | 248 |
| USP30 | FT385, MF094, MF095 | 249 |
| USP47 | Compound 1 | 239 |
| POH1 | 8‐Thioquinoline, capzimin, phen | 247 , 250 , 251 |
| UCHL1 | LDN‐57444, GK13S, 6RK73 | 252 , 253 |
| UCHL5 | IU‐1/analogues, b‐AP15, VLX1570, WP1130, auranofin | 231 , 243 , 244 , 245 , 246 |