TABLE 2.

The role and function of DUBs in related diseases.

Disease name	DUBs	The role and function of DUBs	References
Cancer	USP3, USP4, USP5, USP7, USP11, USP14, USP17, USP27X, USP29, USP36, USP37, USP42, USP46, USP47, A20, CSN5, OTUB1, OTUD4, UCHL1	Upregulation of epithelial–mesenchymal transition in cancer	199 , 284
	USP2A, USP3, USP4, USP6, USP13, USP15, USP16, USP17, USP21, USP22, USP27X, USP28, USP38, USP39, USP42, USP43, USP49, USP51, CSN5, POH1, TRABID, UCHL1, UCHL3, BRCC36, COPS6, COPS5, ATXN3L, ATXN3, OTUD7B, OTUD2	Upregulation of tumor invasion in cancer	284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299
	USP9X, USP53, OTUD3	Downregulation of tumor invasion in cancer	199 , 284 , 300 , 301
	USP3, USP4, USP8, USP9X, USP17, USP22, USP27X, USP29, USP37, USP45, UCHL1	Upregulation of tumor migration in cancer	199 , 284
	USP11, USP53	Downregulation of tumor migration in cancer	199 , 284
	USP1, USP4, USP7, USP10, USP11, USP20, USP21, USP24, USP26, USP33, A20, ataxin 3, CSN5, OTUB2, UCHL1, AMSH, COPS6, COPS5, UCHL5	Upregulation of metastatic dissemination in cancer	199 , 217 , 284 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307
	OTUD1, TRABID, OTUD7A, OTUD6B, CYLD	Downregulation of metastatic dissemination in cancer	199 , 284 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316
Neurodegenerative diseases and other nervous system disorders	ATXN3, USP7, USP8, USP14, USP15, USP30, BAP1, CYLD, PSMD14, TNFAIP3, UCH‐L1, UCHL‐5, USP1, USP4, USP10, USP11, USP12, USP13, USP18, USP22, USP33, USP36, USPL1, USP9X, YOD1	Involved in the upregulation of neurodegeneration formation	61 , 243 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340
	USP16, A20, CYLD, OTULIN, USP18, USP25, UCHL1, UCHL3, UCHL5/UCH37, USP2, USP5, OTUD4, PSMD14, EIF3H, AMSH	Involved in the progression of other nervous system disorders	10 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349
Obesity	USP2, USP7, USP15, USP19, USP20	Involved in the progression of worsening obesity	271 , 350 , 351 , 352
	USP53	Involved in the progression of reducing obesity	271 , 353
T1DM	USP18, USP22	Involved in the progression of worsening T1DM	275 , 277 , 350
T2DM	USP1, USP19, USP21, USP2, USP14, USP20	Involved in the progression of worsening T2DM	354 , 355 , 356 , 357 , 358
	USP22, USP2, USP9X, USP20, USP33, USP4, USP7, USP10, USP18	Involved in the progression of reducing T2DM	356 , 359 , 360 , 361 , 362 , 363 , 364 , 365 , 366