iPSCs
|
Induced pluripotent stem cells |
iPSC-CMs
|
Induced pluripotent stem cell-derived cardiomyocytes |
SR
|
Sarcoplasmic reticulum |
TT
|
Transverse tubule |
E-C
|
Excitation-contraction coupling |
CICR
|
Calcium-induced calcium release |
NCX
|
Sodium/calcium exchanger |
Na/K-ATPase
|
Sodium/potassium ATPase |
InsP3R
|
Inositol triphosphate receptor |
RyR2
|
Ryanodine receptor 2 |
BrS
|
Brugada syndrome |
CPVT
|
Catecholaminergic polymorphic ventricular tachycardia |
CASQ2
|
Calsequestrin 2 |
SQTS
|
Short QT syndrome |
ICC
|
Inherited cardiac channelopathies |
OSKM
|
Oct3/4, Sox2, Klf4 and c-Myc |
LQTS
|
Long-QT syndrome |
APD
|
Action potential duration |
EADs
|
Early afterdepolarizations |
DADs
|
Delayed afterdepolarizations |
EHT
|
Engineered heart tissues |
VUS
|
Variants of uncertain significance |
CRISPRi/a
|
CRISPR-based interference and activation system |
dCas9
|
Deactivated Cas9 |
ChR2
|
Channelrhodopsin |
CTD
|
Calcium transient duration |
EHM
|
Engineered heart muscle |
T3
|
Triiodothyronine |
Dex
|
Dexamethasone |
NRVM
|
Neonatal rat ventricular cardiomyocytes |
iPSC-CMs-ChR2
|
iPSC-CMs expressing Channelrhodopsin |