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. 2024 Sep 12;15:1475152. doi: 10.3389/fphys.2024.1475152
iPSCs Induced pluripotent stem cells
iPSC-CMs Induced pluripotent stem cell-derived cardiomyocytes
SR Sarcoplasmic reticulum
TT Transverse tubule
E-C Excitation-contraction coupling
CICR Calcium-induced calcium release
NCX Sodium/calcium exchanger
Na/K-ATPase Sodium/potassium ATPase
InsP3R Inositol triphosphate receptor
RyR2 Ryanodine receptor 2
BrS Brugada syndrome
CPVT Catecholaminergic polymorphic ventricular tachycardia
CASQ2 Calsequestrin 2
SQTS Short QT syndrome
ICC Inherited cardiac channelopathies
OSKM Oct3/4, Sox2, Klf4 and c-Myc
LQTS Long-QT syndrome
APD Action potential duration
EADs Early afterdepolarizations
DADs Delayed afterdepolarizations
EHT Engineered heart tissues
VUS Variants of uncertain significance
CRISPRi/a CRISPR-based interference and activation system
dCas9 Deactivated Cas9
ChR2 Channelrhodopsin
CTD Calcium transient duration
EHM Engineered heart muscle
T3 Triiodothyronine
Dex Dexamethasone
NRVM Neonatal rat ventricular cardiomyocytes
iPSC-CMs-ChR2 iPSC-CMs expressing Channelrhodopsin