Figure 3.

An example of a team (δ = 3) found in E. coli and S. typhi, corresponding to proteins that belong to the so-called “two-components regulatory system.” The figures near the arrows are the BLAST E-values corresponding to the pairwise alignments of the proteins. It can be seen that the proteins YfhK and PgtB share but little sequence similarity, preventing this team from being detected by automated methods based on sequence comparisons. Similarly, PgtB and STY2811 are poorly similar, but the use of their Pfam labels led to pinpointing the duplication in S. typhi.