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Ad5AGS3 AS eliminates heroin-seeking behavior in rats. AS for AGS3 (Ad5AGS3 AS, 2 μl per side, 1012 plaque-forming units/ml) was infused into the core or the shell of the NAc. AGS3 AS in the core of the NAc prevented reinstatement of lever pressing elicited by a priming injection of heroin. Data represent mean active lever presses ± SEM, n = 8 in all groups. *, P < 0.01, compared with extinction responding (EXT) (two-way ANOVA, Tukey's posttest).
