Table 4. Infection episodes before study entry and in 1 year of study participation.
| Infections before study entry and mean (AIRs). | |||
|---|---|---|---|
| SID patients | SID patients with IVIG before NIS | SID patients without IVIG before NIS | |
| (N = 1644) | (N = 595) | (N = 1,049) | |
| Number of infections in the last 3 monthsa and (AIR)b | 843 (3.7) | 237 (3.0) | 606 (4.0) |
| Number of antibiotic-requiring infections in the last 3 monthsa and (AIR)b | 613 (2.7) | 160 (3.1) | 453 (2.0) |
| Number of infections requiring hospitalization in the last 3 monthsa and (AIR)b | 114 (0.5) | 29 (0.4) | 85 (0.6) |
| AIR in the first year of the NIS | |||
| Annual infection rate – all infections | 1.1 | 1.3 | 1.0 |
| AIR for infections requiring antibioticsc | 0.6 | 0.7 | 0.6 |
| AIR for infections requiring hospitalization | 0.2 | 0.2 | 0.2 |
Total N = 1,644. Not all 1,644 patients provided information on whether they had an infection before NIS entry. aThe numbers for the last 3 months before study participation relied on the patients’ recollection. bThe annual infection rate was calculated on the basis of 3-month values and patients with data available. cIncluding patients with antibiotic prophylaxis. AIR = annual infection rate; SID = secondary immunodeficiency; NIS = large-scale non-interventional study.