Table 1.
Characteristic | Detail | Advantage vs | |
Tumor cell antigen sources | adoptive cellular therapy | ||
Pure | Avoid tolerizing cellular antigens; exclude normal protein, avoid autoimmunity. | X | |
Processed | Avoid effects of immunoproteasome | X | |
Cheap | Feasible to study without corporate support | X | X |
Easier | Lower regulatory hurdles | X | X |
Evaluable | Excellent cancer vaccine model, allowing direct evaluation of response to the specific immunogen | X | |
Modifiable | Create synthetic peptides better than native peptides | X | |
Immunogenic | Induce T cell responses in patients | ||
Combinable | Multipeptide vaccines may mimic immune effects of whole cell vaccines. |