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Schematic diagram showing that CCDC68 ensures proper chromosome segregation by promoting CDC20 integration into the MCC. CCDC68 is recruited to unaligned kinetochores during prometaphase. CCDC68 interacts with CDC20 and MAD2 to inhibit the autoubiquitination of CDC20 and restrains the turnover of the MCC on the APC/C, thus maintaining the strength of the SAC and the fidelity of chromosome alignment.
