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Single-cell mRNA transcriptional analysis of Aire-deficient medullary thymic epithelial cells cocultured with wild-type CD4+ thymocytes. (A) UMAP clustering of TECs (TEC, mTEC I, mTEC II, and CD4+ thymocytes) based on their transcriptional profiles. (B) mTECs were identified based on their expression of Epcam, Itgb4, Itgb6 and Casp3 mRNA markers (B1), proliferative TECs based on Ccna2, Pbk and Birc5 expression (B2), and naïve CD4+ thymocytes based on Ilr7 and Ccr7 expression (B3).
