Figure 5.

Uterine luminal epithelium staining of p53 and MYC. A, A WT mouse at 12 months of age showing negative p53 and MYC staining in the uterine epithelium and positive staining in adjacent tissues. B, Example of a 12 months old OvTrpMyc mouse with cytoplasmic p53 and whole-cell MYC staining along the ULE. C, A large retroperitoneal tumor, behind the kidney, stained for p53, MYC, and PAX8. D, An example of ULE expression in an OvTrpMyc mouse F129, with evidence of similar whole-cell staining of p53 and MYC on the (E) OSE and (F) ovarian fat pad metastasis. Mouse F129 was 11 months of age. G, Proposed model for observed dissemination of cells from the FTE to the ULE as an origin of uterine serous carcinoma. USC, uterine serous carcinoma.