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The sequence of human METTL1 and the location of its functional domains. The phosphorylation site is at residue 27, a putative SAM-binding motif (GXGXG) between residues 58 and 65, and a motif similar to that found in an rRNA methylase (rRNA met) of C. trachomatis was found between residues 156 and 200 (Bahr et al, 1999).
