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. 2024 Aug 25;65(9):100633. doi: 10.1016/j.jlr.2024.100633

Fig. 7.

Fig. 7

DRP1 knockout in adipose tissue triggers local inflammation. (A, B) Representative IF staining of MAC2 in the BAT of WT and KO mice fed on NCD (A) or HFD (B) (Scale bars: 100 μm). (C) Representative IF staining of CD68 in the BAT of WT and KO mice after HFD feeding (Scale bars: 100 μm). (D) Representative IF staining of MAC2 in the eWAT and sWAT of WT and KO mice after HFD feeding (Scale bars: 100 μm). (E) qPCR analysis of inflammation-related genes in the BAT of WT and KO mice fed on HFD (n = 4/group). Scale bar = 100 μm. ∗P < 0.05, ∗∗P < 0.01, unpaired Student’s t test. BAT, brown adipose tissue; DRP1, dynamin-related protein 1; eWAT, epididymal WAT; HFD, high-fat diet; IF, immunofluorescent; qPCR, quantitative-PCR; NCD, normal chow diet; sWAT, subcutaneous WAT.