Clinical trials of therapeutic exosomes^a.

Clinical trial ID	Status	Cancer	Exosomes source	Clinically significant	Funding
NCT01294072	Recruiting	Colon cancer	Plant exosomes	Phase I clinical trial investigating the ability of plant exosomes to deliver curcumin to normal and malignant colon tissue	University of Louisville
NCT03608631	Active, not recruiting	Metastatic pancreas cancer	Mesenchymal stromal cells-derived exosomes (with KrasG12D)	Phase I study of mesenchymal stromal cells-derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring KrasG12D mutation	M.D. Anderson cancer center
NCT01159288	Completed	Unresectable non small cell lung Cancer	Vaccination with tumor antigen-loaded dendritic cell-derived exosomes	Phase II trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes on patients with unresectable non small cell lung cancer responding to induction chemotherapy	Gustave roussy, cancer campus, Grand Paris
NCT06245746	Not yet recruiting	Acute myeloid leukemia (after achieving complete remission)	Umbilical cord derived mesenchymal stem cells exosomes (UCMSC-Exo)	A single-center, prospective trial of the safety and efficacy of UCMSC-Exo in consolidation chemotherapy-induced myelosuppression in patients with acute myeloid leukemia after achieving complete remission	Wuhan Union Hospital, China
NCT01668849	Completed	Oral mucositis associated with chemoradiation treatment of head and neck cancer	Edible plant (grape) exosome	Preliminary clinical trial investigating the ability of plant exosomes to abrogate oral mucositis induced by combined chemotherapy and radiation in head and neck Cancer patients	University of Louisville

^aSource: https://clinicaltrials.gov/.