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. 2024 Sep 18;108:105330. doi: 10.1016/j.ebiom.2024.105330

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Results of differential gene expression analysis based on RNA bulk-sequencing during liver normothermic machine perfusion at different time-points compared to baseline (PRE). (a) Experimental design for paired analysis. (b) Volcano plots indicating significantly up- or downregulated genes (average normalized counts >10, more than two-fold change and false discovery rate (FDR) <0.1) at different time-points compared to baseline (PRE). (c) Dot plot indicating number of overlapping significantly up-regulated genes (red) or significantly down-regulated genes (blue). (d) Heatmap indicating log2 fold changes at different time points from significantly differentially expressed genes in at least on time point compared to baseline before NMP (PRE) and mean log2 fold change of top 40 up- and down regulated genes.