Fig. 2.

Functional analyses of differentially expressed genes. (a) ClueGO analyses indicating biological processed upregulated during liver NMP. Most relevant terms are highlighted. Connection between nodes (biological processes) indicate shared genes based on kappa statistics. (b) Gene set enrichment analyses for 50 hallmark gene sets with normalized enrichment score is indicated by size and significance (false discovery rate (FDR) <0.1) by strong border. Gene sets enriched in upregulated genes (positive enrichment) is indicated in red, gene sets enriched in downregulated genes (negative enrichment) is indicated in blue. (c–h) Different clusters of up-regulated genes and their related protein interactions using the STRING database and MCL clustering; connections indicate (different) evidences for interactions.