Fig. 4.

Gene set enrichment analyses indicate a signature of ischemia-reperfusion injury (IRI) is highly enriched in upregulated genes during liver normothermic machine perfusion (NMP). (a) Enrichment plots for different time points. (b) Heatmap indicating log2 fold change of genes which are also included in the IRI signature, dots indicate that genes are included in core enrichment (this refers to genes before the maximum enrichment is reached). (c) Venn diagrams indicating the number of overlapping significantly upregulated (downregulated) genes between 1 h and before NMP and upregulated (downregulated) genes between transplanted livers (POST) and the last time point (20 h) of NMP.