Comparison 1. Daily cotrimoxazole (CTXp) with any other drug regimen (mefloquine (MQ) or dihydroartemisinin‐piperaquine (DHA‐PPQ)) versus CTXp with or without placebo (current standard of care).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Maternal peripheral parasitaemia at delivery (amplification techniques)	5	2406	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.41, 0.95]
1.2 Maternal peripheral parasitaemia at delivery (microscopy)	3	1614	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.17, 3.58]
1.3 Maternal anaemia at delivery (< 11 g/dL)	3	2417	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.90, 1.07]
1.4 Placental malaria (any test)	5	2690	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.42, 1.03]
1.5 Placental malaria (blood smear)	3	1337	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.31, 0.93]
1.6 Placental malaria (amplification techniques)	3	1171	Risk Ratio (M‐H, Random, 95% CI)	0.45 [0.09, 2.19]
1.7 Placental malaria (histopathologic analysis)	3	1570	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.50, 0.90]
1.8 Maternal peripheral parasitaemia during pregnancy (any test)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.9 Clinical malaria episodes during pregnancy	4		Rate Ratio (IV, Fixed, 95% CI)	0.67 [0.35, 1.32]
1.10 Mean haemoglobin at delivery (in g/dL)	4	2145	Mean Difference (IV, Random, 95% CI)	‐0.06 [‐0.28, 0.17]
1.11 Maternal severe anaemia at delivery (< 7 g/dL)	4	2621	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.73, 1.98]
1.12 Low birth weight (less than 2500 g)	5	2915	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.95, 1.41]
1.13 Mean birth weight (g)	4	2718	Mean Difference (IV, Fixed, 95% CI)	‐46.90 [‐85.96, ‐7.84]
1.14 Cord blood parasitaemia (blood smear)	5	2696	Risk Ratio (M‐H, Fixed, 95% CI)	0.27 [0.04, 1.64]
1.15 Cord blood parasitaemia (loop‐mediated isothermal amplification)	1	190	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
1.16 Prematurity	5	2401	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.78, 1.47]
1.17 Severe adverse events during pregnancy	4	2797	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.60, 0.97]
1.18 Foetal loss	5	2957	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.73, 1.46]
1.19 Congenital malformations	5	2904	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.51, 1.58]
1.20 Maternal mortality	4	2787	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.27, 2.65]
1.21 Neonatal mortality	4	2706	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.68, 2.14]