Comparison 2. Mefloquine (MQ) plus daily cotrimoxazole (CTXp) versus CTXp.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Maternal peripheral parasitaemia at delivery (polymerase chain reaction)	2	989	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.30, 0.93]
2.2 Maternal anaemia at delivery (< 9.5 g/dL)	2	1197	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.73, 1.20]
2.3 Placental malaria (blood smear)	2	1144	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.29, 0.89]
2.4 Placental malaria (polymerase chain reaction)	2	977	Risk Ratio (M‐H, Fixed, 95% CI)	0.28 [0.14, 0.57]
2.5 Clinical malaria episodes during pregnancy	1		Rate Ratio (IV, Fixed, 95% CI)	Subtotals only
2.6 Mean haemoglobin at delivery (in g/dL)	2	1167	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.32, 0.46]
2.7 Maternal severe anaemia at delivery	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.8 Low birth weight (< 2500 g)	2	1220	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.89, 1.60]
2.9 Mean birth weight (g)	2	1220	Mean Difference (IV, Fixed, 95% CI)	‐25.75 [‐86.99, 35.49]
2.10 Cord blood parasitaemia	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.11 Prematurity	2	824	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.58, 1.96]
2.12 Severe adverse events during pregnancy	2	1347	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.50, 0.95]
2.13 Foetal loss	2	1347	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.42, 2.98]
2.14 Congenital malformations	2	1312	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.22, 1.67]
2.15 Maternal mortality	2	1347	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.13, 2.01]
2.16 Neonatal mortality	2	1239	Risk Ratio (M‐H, Fixed, 95% CI)	1.32 [0.65, 2.69]
2.17 Adverse events: headache	2	1347	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.28, 2.10]
2.18 Adverse events: vomiting	2	1347	Risk Ratio (M‐H, Random, 95% CI)	20.88 [1.40, 311.66]
2.19 Adverse events: dizziness	2	1347	Risk Ratio (M‐H, Random, 95% CI)	16.34 [0.39, 684.99]
2.20 Adverse events: fatigue/weakness	2	1347	Risk Ratio (M‐H, Random, 95% CI)	2.95 [0.26, 32.93]
2.21 Mother‐to‐child transmission of HIV	2	1019	Risk Ratio (M‐H, Fixed, 95% CI)	1.92 [1.13, 3.25]
2.22 Undetectable viral load	2	1220	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.81, 1.08]