Menéndez 2008.

Study characteristics
Methods	Randomized, double‐blind, placebo‐controlled trial
Participants	207 HIV‐positive pregnant women in Southern Mozambique Inclusion criteria Attending the Manhiça District Hospital antenatal care clinic (Mozambique) Gestational age equal or below 28 weeks Permanent residents in the study area Exclusion criteria Allergies to sulfa drugs
Interventions	2 doses of SP for IPTp delivered through antenatal clinics vs placebo
Outcomes	The primary study outcome was low birth weight. Secondary outcomes were maternal peripheral parasitaemia at delivery, placental malaria, haemoglobin level at delivery, maternal anaemia, maternal viral load at delivery, prematurity rate, mean birth weight, and mother‐to‐child transmission of HIV. Of note, this trial also assessed safety outcomes for the overall sample of HIV‐positive and uninfected women. We requested disaggregated data by HIV‐status, but safety outcomes could not be retrieved for the subgroup of HIV‐positive women.
Notes	All participants received an LLIN. All participants were given nevirapine prophylaxis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	A computer‐generated sequential list contained the study numbers linked to treatment identification letters, randomly ordered in blocks of 10. After written informed consent was obtained, the lowest available study number was assigned.
Allocation concealment (selection bias)	Unclear risk	Allocation was stored in a computer‐generated list, but there is no information about where this list was kept or who had access to it.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	This study was a double‐blind, placebo‐controlled trial. Tablets of SP or placebo, identical in shape and colour, were stored in 10 bottles labelled only with a single treatment identification letter. Women were randomized to receive 3 tablets of SP (1500 mg sulphadoxine/75 mg pyrimetamine) or placebo.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	As nurses and doctors were blinded, and the principal outcome of the study was low birth weight, we judged the study to have a low risk of detection bias.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	The paper does not explain why a few children did not have data on weight, or whether baseline characteristics were balanced among those who were weighed and those who were not.
Selective reporting (reporting bias)	Low risk	Not observed
Other bias	Low risk	Not observed