NCT00164255.

Study name	Efficacy of intermittent sulfadoxine‐pyrimethamine and sulfadoxine‐pyrimethamine + artesunate treatment in the prevention of malaria in pregnancy in an area with chloroquine‐resistant Plasmodium falciparum
Methods	Open‐label RCT
Participants	1614 pregnant women with and without HIV infection in Tanzania
Interventions	Sulfadoxine/pyrimethamine and sulfadoxine/pyrimethamine plus artesunate
Outcomes	The primary outcomes are placental parasitaemia and reported or noted adverse reactions. Secondary outcomes are parasitaemia at delivery (maternal peripheral, placental and cord), maternal illness, birth weight, gestational age, foetal and infant health, impact of maternal HIV infection on efficacy of malaria prevention during pregnancy.
Starting date	January 2003
Contact information	John MacArthur, Centers for Disease Control and Prevention
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