PACTR201612001901313.

Study name	Effectiveness of the combination of dihydroartemisinin and piperaquine for prevention of falciparum malaria during pregnancy in Tanzania
Methods	Blinded RCT
Participants	200 women with HIV infection in Tanzania
Interventions	Daily co‐trimoxazole alone versus dihydroartemisinin/piperaquine added to daily cotrimoxazole
Outcomes	The primary outcome is active or recent placental malaria measured at delivery Secondary outcomes are incidence of malaria infection and clinical malaria during pregnancy, defined as fever or recent history of fever in the presence of malaria parasites; and prevalence of adverse newborn morbidity at birth, defined as a composite of either preterm delivery (< 37 weeks' gestation), low birth weight (< 2500 g), and, anaemia (haemoglobin<11 g/dL) during pregnancy or at delivery.
Starting date	7 November 2016
Contact information	Mwelecele Malcela, National Institute for Medical Researches
Notes

Abbreviations: AIDS: acquired immunodeficiency syndrome; CTXp: daily cotrimoxazole prophylaxis; HIV: human immunodeficiency virus; IPTp: intermittent preventive treatment in pregnancy; RCT: randomized controlled trial; SP: sulfadoxine‐pyrimethamine; STI: sexually transmitted infection; vs: versus