Figure 9.

Intermittent cistern magna CSF drain alleviated PVS enlargement, hydrocephalus, and neurological and cognitive deficits in SAH beagles. (A) Left, representative hematoxylin-eosin staining showing the PVS 2 weeks after SAH with or without intermittent cistern magna CSF drain treatment; Right, quantification of the Left images. (B) Quantification of the lateral ventricle volume in SAH and SAH + CSF drain beagles 1 week and 2 weeks after SAH. Intermittent cistern magna CSF drain decreased the lateral ventricle volume in SAH beagles. (C) Quantification of Evan's index in SAH and SAH + CSF drain beagles 1 week and 2 weeks after SAH. (D) Quantification of the Neurological Deficit Scores in SAH and SAH + CSF drain beagles 1 week and 2 weeks after SAH. (E) Quantification of the cognitive test scores in SAH and SAH + CSF drain beagles 1 week and 2 weeks after SAH. Student t test, n = 3; & P < 0.05, compared to the SAH group. CSF: cerebrospinal fluid; PVS: perivascular space; SAH: subarachnoid hemorrhage.