Table 2.
Proportion of Patients With Negative Blood Culture After the First Dose of the Study Drug and Time From the First Dose of the Study Drug to Negative Blood Culture
| Rezafungin (400/200 mg) (N = 30) | Caspofungin (70/50 mg) (N = 35) | |
|---|---|---|
| Patients with NBC,a n (%) | 26/30 (86.7) | 24/35 (68.6) |
| Patients censored,b n (%) | 4/30 (13.3) | 11/35 (31.4) |
| TTNBC,c h | ||
| Median (95% CI) | 23.9 (12.3, 90.3) | 60.5 (27.0, 112.6) |
| P valuec | .094 | |
| Patients with NBC,a n (%) | ||
| At 24 h | 16/29 (55.2) | 9/33 (27.3) |
| Patients censoredb | 1 (3.3) | 2 (6.0) |
| P valued | .0162 | |
| At 48 h | 17/29 (58.6) | 14/32 (43.8) |
| Patients censoredb | 1 (3.4) | 3 (5.7) |
| P valued | .2460 |
Only patients with a positive blood culture close to randomization and who received ≥1 dose of the study drug were included in this analysis.
Abbreviations: CI, confidence interval; NBC, negative blood culture; TTNBC, time to first negative blood culture.
aWithout subsequent positive culture.
bPatients were censored if they received an alternative antifungal (ie, other than the study drug) for the treatment of the candidemia, died, or were lost to follow-up prior to having the negative blood culture.
cNominal, from log-rank test.
dNominal, from chi-squared test.