Table 1. Drugs predicted to act in Acinetobacter baumannii proteins and selected to be tested against strain ATCC 19606.
| Drug | Original Indication | Original Target | A. baumannii Predicted Target/ UniProt ID | Evolutionary Conservation Rate (%)a | MIC b | |
|---|---|---|---|---|---|---|
| μg/ml | μM | |||||
| Tavaborole | Antifungal | Leucyl-tRNA synthetase | Leucyl-tRNA synthetase (A0A7Z1WR47) | 59.0 | 2 | 13.2 |
| Ribavirin | Antiviral | Inosine-5’-monophosphate dehydrogenase; RNA-directed RNA polymerase | Inosine-5’-monophosphate dehydrogenase (P31002) | 59.0 | 4 | 16.4 |
| Leflunomide | Immunosuppressant | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (B0V824) | 67.0 | 64 | 236.8 |
| Atovaquone | Antiprotozoal | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (B0V824) | 67.0 | 256 | 697.9 |
| Homoharringtonine | Anticancer | 50S ribosomal protein L2; 60S ribosomal protein L3 | 50S ribosomal protein L2 (B0V6X1) | 58.0 | 256 | 469.2 |
| Thiabendazole | Anthelmintic | Fumarate reductase flavoprotein subunit; Succinate dehydrogenase; Cytochrome P450 | Succinate dehydrogenase (A0A2S4TCK3) | 51.0 | 512 | 2544.1 |
| MKT-077 | Anticancer | Heat shock protein 70 (HSP 70) | DnaK protein chaperone (A3M8W9) | 93.6 | 1024 c | 2370.4 |
Note:
a Rate of shared conserved residues.
b Minimum Inhibitory Concentration.
c Minimum Bactericidal Concentration.