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Development of antibodies in rabbits. Six animals (A1 to A6) were immunized with DNA expressing the unmodified SF162 gp140 immunogen, and six (A7 to A12) were immunized with DNA expressing the modified ΔV2 gp140 immunogen. Titers were determined 2 weeks following each immunization, as described in Materials and Methods, against the oligomeric SF162 and ΔV2 gp140 proteins. Dashed lines indicate times of immunizations.
