Figure 3.

Epigenetic alterations are linked to sporadic and familial FTD/ALS. Columns indicate histone post-translational modifications (PTMs), genes, histone-modifying enzymes (HMEs), and chromatin-associated proteins (CAPs) altered in PD. Columns are omitted when no changes are revealed. Yellow arrows denote increases in the levels of proteins, genes, or histone post-translational modifications, while blue arrows denote protein, gene, or post-translational modification level decreases. Black arrows denote binding interactions. Colored dots indicate the model system as depicted in the legend. Global heterochromatin gain is indicated in yellow font, while global heterochromatin loss is indicated in blue font. Figure created with Biorender.com.