Table 1.

Effect of 18KHT01 on weights of vital organs of male and female mice in 30 days subacute toxicity study.

Organs	Male			Female
	Control	18KHT01 (mg/kg)		Control	18KHT01 (mg/kg)
		100	500		100	500
Fasting body weight (g)	41.31 ± 2.06	39.55 ± 2.42	37.76 ± 2.95	31.87 ± 0.28	33.12 ± 2.2	31.31 ± 3.7
Liver (g)	1.63 ± 0.18	1.41 ± 0.11	1.37 ± 0.22	1.20 ± 0.12	1.34 ± 0.14	1.13 ± 0.27
Liver (% of body weight)	3.95 ± 0.37	3.56 ± 0.13	3.61 ± 0.37	3.76 ± 0.34	4.04 ± 0.24	3.60 ± 0.62
Kidney (g)	0.65 ± 0.03	0.51 ± 0.1∗∗	0.52 ± 0.07∗∗	0.37 ± 0.05	0.37 ± 0.03	0.40 ± 0.04
Kidney (% of body weight)	1.57 ± 0.10	1.28 ± 0.1∗∗	1.37 ± 0.14∗	1.16 ± 0.14	1.12 ± 0.06	1.29 ± 0.04
Spleen (g)	0.10 ± 0.02	0.11 ± 0.02	0.10 ± 0.02	0.13 ± 0.02	0.17 ± 0.04	0.13 ± 0.03
Spleen (% of body weight)	0.25 ± 0.05	0.26 ± 0.03	0.26 ± 0.05	0.39 ± 0.07	0.50 ± 0.10	0.42 ± 0.08
Heart (g)	0.23 ± 0.02	0.19 ± 0.03	0.18 ± 0.03∗	0.16 ± 0.03	0.20 ± 0.03	0.19 ± 0.03
Heart (% of body weight)	0.55 ± 0.07	0.47 ± 0.07	0.47 ± 0.04	0.50 ± 0.08	0.61 ± 0.07	0.59 ± 0.07
Lungs (g)	0.23 ± 0.03	0.21 ± 0.01	0.21 ± 0.01	0.20 ± 0.02	0.22 ± 0.02	0.24 ± 0.05
Lungs (% of body weight)	0.56 ± 0.08	0.53 ± 0.06	0.56 ± 0.06	0.62 ± 0.06	0.68 ± 0.07	0.77 ± 0.1∗
Testes (g)	0.27 ± 0.03	0.25 ± 0.03	0.25 ± 0.06	—	—	—
Testes (% of body weight)	0.65 ± 0.07	0.63 ± 0.07	0.66 ± 0.13	—	—	—
Ovary (g)	—	—	—	41.43 ± 15.45	39.58 ± 9.1	34.26 ± 6.5
Ovary (% of body weight)	—	—	—	0.13 ± 0.05	0.12 ± 0.04	0.11 ± 0.03
Brain (g)	0.49 ± 0.02	0.49 ± 0.02	0.48 ± 0.02	0.49 ± 0.01	0.49 ± 0.01	0.49 ± 0.05
Brain (% of body weight)	1.18 ± 0.09	1.23 ± 0.09	1.27 ± 0.11	1.54 ± 0.03	1.48 ± 0.09	1.58 ± 0.16

Note: Statistical significance was calculated using one-way ANOVA followed by Dunnett's multiple comparisons test. Results are presented as the mean ± standard deviation (n = 5) with significance.

^∗ p < 0.05 vs. controls of the respective sex group.

^∗∗ p < 0.01 vs. controls of the respective sex group.