FIGURE 1.

(a) Mice receiving LN exhibited significant increases in 12‐h (dark hours) average mean arterial pressure measured telemetrically. (b) Mice receiving LN exhibited decreased heart rates (measured via echocardiography), consistent with the baroreceptor reflex. (c, d) Both groups receiving LN exhibited elevated mitral E/A and E/e' ratios. (e, f) HFLN+ mice exhibited a mild hyper‐contractile phenotype after 18 weeks of treatment. (g, h) Representative mitral inflow and tissue annulus Doppler traces indicate the development of grade 3 diastolic dysfunction in hypertensive mice. Panel (a): N = 4–5/group; (b–f): N = 15/group. As for all figures, pairwise significant differences were determined with Sidak's multiple comparison post‐hoc analysis performed only on factors determined to be significant (p < 0.05) via two‐way ANOVA.