Figure 4.
Exosomal miR-30a-5p enhanced migration and invasion ability of NPC cells. (A) The ability of cell migration (top) and invasion (bottom) after transfection of miR-30a-5p inhibitor in S18 cells. Representative images are shown on the right. The ability of cell migration (top) and invasion (bottom) after transfection of miR-30a-5p mimic in CNE-2 (B) and S26 (C) cells. Representative images are shown on the right. (D) Relative expression of miR-30a-5p in miR-30a-5p overexpression or control cells. (E) Relative expression of miR-30a-5p in exosomes derived from miR-30a-5p overexpression and control cells. (F–H) After treatment with exosomes from miR-30a overexpression and control cells, the expression of miR-30a-5p (F), migration (G), and invasion (H) ability of CNE-2 cells. Representative images are shown on the right. (I–K) After treatment with exosomes from miR-30a overexpression and control cells, the expression of miR-30a-5p (I), migration (J), and invasion (K) ability of S26 cells. Representative images are shown on the right. *, p<0.05; **, p<0.01; ***, p<0.001.