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(A) Maximum tolerable dose for peptide 1 (Native) and peptide 11, PMB was calculated using Swiss female mice (weighing 22–28 g and aged 7 weeks). All mice were administered an intravenous bolus of the peptides (mg/kg free base) via a lateral tail vein (≤0.1 mL). (B) Efficacy of laterocidine (peptide 1) and peptide 11 in a bloodstream infection murine model by P. aeruginosa FADDI-PA070. Laterocidine analogues (8 mg/kg, N = 3, 4 h time point).
