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(A) Representative structure of BET proteins. (B) Functions of BET family member BRD4 in the regulation of promoter. BRD4 binds to acetylated lysine (COCH3) in histones or transcription factors (TF) via its BD1 and BD2 domains. The binding of acetylated histones by BRD4, at transcription start sites (TSS), mediates transcriptional co-activation and elongation via RNA polymerase II (RNA pol II) and Mediator (Med) and positive transcription elongation factor B (P-TEFb) signaling complexes
