Table 2.
Uni- and multivariable Cox regression for the predictive factors of biochemical recurrence in the whole study cohort
| Characteristic | Univariable | Multivariable | ||||||
|---|---|---|---|---|---|---|---|---|
| N | OR | 95% CI | p-value | N | OR | 95% CI | p-value | |
| Age at therapy (years) | 411 | 0.99 | 0.96, 1.03 | 0.7 | 411 | 0.96 | 0.92, 1.00 | 0.077 |
| PSA (ng/ml) <10 10–20 >20 |
411 Ref |
– 2.31 3.46 |
– 1.29, 4.08 1.01, 10.8 |
0.004 0.036 |
411 |
– 1.37 1.08 |
– 0.69, 2.62 0.28, 3.95 |
0.4 >0.9 |
| Prostate volume (cc) | 411 | 1.01 | 1.00, 1.02 | 0.2 | 411 | 1.01 | 0.99, 1.03 | 0.2 |
| ISUP specimen 2 3 4 5 |
411 Ref |
– 3.60 6.93 7.62 |
– 1.98, 6.80 2.30, 20.1 3.26, 17.9 |
<0.001 <0.001 <0.001 |
411 |
– 2.86 5.90 4.63 |
– 1.49, 5.65 1.81, 18.6 1.79, 11.9 |
0.002 0.003 0.001 |
| Pathological stage T2 T3a T3b |
411 Ref |
– 2.83 13.9 |
– 1.61, 5.12 5.63, 36.2 |
<0.001 <0.001 |
411 |
– 1.70 6.20 |
– 0.89, 3.31 2.25, 17.7 |
0.11 <0.001 |
| Surgical margin Negative Positive |
411 Ref |
– 2.23 |
– 1.33, 3.70 |
0.002 |
411 |
– 1.55 |
– 0.85, 2.80 |
0.15 |
| Largest tumour diameter (mm) | 411 | 1.06 | 1.03, 1.09 | <0.001 | 411 | 1.03 | 0.99, 1.07 | 0.10 |
OR – odds ratio; CI – confidence interval; PSA – prostate-specific antigen