Table 3.
Modified hydrogel was used as culture substrates
| Source | Addition | Cultivate | Extracellular matrix component source | Enhancement aspect | References |
|---|---|---|---|---|---|
| Plant | Alginate | Mouse preovarian follicle | Human and bovine ovarian | Oocyte maturation rate was significantly improved | [117] |
| Agarose | Patient-derived bone MSCs and CDCs | Patient’s cartilage | The proliferation rate of CDC and MSC was increased | [118] | |
| Animal | Hyaluronic acid and collagen | Patient-derived sarcoma organoids | Patient’s sarcoma | Providing a more tumor-like environment in vivo facilitates drug screening | [119] |
| Fibrinogen | Rat neonatal cardiomyocytes | Pig ventricular | Better spontaneous heartbeat recovery, frequency, synchronization and maintenance | [113] | |
| Synthesis | Epoxyeicosatrienoic acid (EET) | Rabbit esophageal epithelial cells | Pig esophagus | The metabolic activity of rabbit epithelial cells was improved | [120] |
| Hyaluronic acid methacrylate (HAMA) | Mouse pancreatic cells | Mouse pancreatic | Maintain the adhesion and morphology of islet cells and improve islet function and activity | [121] |