Table 1.
Demographic and clinical characteristics of the studies included in the discovery cohort
| Current PTSD | ||||
|---|---|---|---|---|
| Cases | Controls | P value | Total | |
| N | ||||
| Army STARRS | 42 | 111 | 153 | |
| DNHS | 31 | 385 | 416 | |
| GTP | 161 | 323 | 484 | |
| MRS I&II | 63 | 60 | 123 | |
| PRISMO | 17 | 33 | 50 | |
| All | 314 | 912 | 1226 | |
| Gender, Male (%) | ||||
| Army STARRS | 42 (27) | 111 (73) | 153 (100) | |
| DNHS | 10 (2) | 161 (39) | 171 (41) | |
| GTP | 25 (5) | 107 (22) | 132 (27) | |
| MRS I&II | 63 (51) | 60 (49) | 123 (100) | |
| PRISMO | 17 (34) | 33 (66) | 50 (100) | |
| All | 157 (50) | 472 (51.8) | 629 (51.3) | |
| Age, mean (SD) | ||||
| Army STARRS | 25.8 (5.1) | 25.5 (5.2) | 7.54E-01 | 25.6 (5.2) |
| DNHS | 51.6 (11.1) | 55.6 (17.1) | 7.66E-02 | 55.3 (16.8) |
| GTP | 41.7 (11.4) | 42.4 (12.5) | 5.48E-01 | 42.2 (12.1) |
| MRS I&II | 23.3 (2.3) | 22.9 (1.9) | 3.59E-01 | 23.1 (2.1) |
| PRISMO | 28.1 (10.1) | 27.5 (9.1) | 8.29E-01 | 27.7 (9.3) |
| All | 36.1 (13.4) | 44.1 (18) | 5.89E-16 | 42.1 (17.3) |
| PTSD symptom severity, mean (SD) | ||||
| Army STARRS | 56.9 (9.6) | 22.4 (5.8) | 4.83E-28 | 32 (17) |
| DNHS | 63 (16) | 32.7 (11.4) | 1.89E-11 | 34.9 (14.2) |
| GTP | 70.4 (18.6) | 25.1 (16.9) | 2.17E-32 | 38.5 (27.1) |
| MRS I&II | 65.4 (14.8) | 13.6 (11.8) | 1.30E-42 | 40.2 (29.2) |
| PRISMO | 42 (4.4) | 27 (4.8) | 6.72E-13 | 32.1 (8.5) |
| All | 63.1 (16.7) | 27.7 (13.3) | 5.88E-88 | 35.8 (20.5) |
| Self-reported Race/Ethnicity, N (%) | ||||
| Army STARRS | ||||
| African American | 3 (2) | 12 (7.8) | 15 (9.8) | |
| White | 29 (19) | 88 (57.5) | - | 117 (76.5) |
| Other | 10 (6.5) | 11 (7.2) | - | 21 (13.7) |
| DNHS | - | |||
| African American | 28 (6.7) | 381 (91.6) | - | 409 (98.3) |
| Other | 3 (0.7) | 4 (1) | - | 7 (1.7) |
| GTP | - | |||
| African American | 153 (31.6) | 307 (63.4) | - | 460 (95) |
| Other | 8 (1.7) | 16 (3.3) | - | 24 (5) |
| MRS I&II | - | |||
| African American | 2 (1.6) | 2 (1.6) | 4 (3.3) | |
| White | 53 (43.1) | 53 (43.1) | - | 106 (86.2) |
| Other | 8 (6.5) | 5 (4.1) | - | 13 (10.6) |
| PRISMO | - | |||
| African American | 1 (2) | 1 (2) | - | 2 (4) |
| White | 11 (22) | 27 (54) | - | 38 (76) |
| Other | 5 (10) | 5 (10) | - | 10 (20) |
| All | ||||
| African American | 187 (59.6) | 703 (77.1) | - | 890 (72.6) |
| White | 93 (29.6) | 168 (18.4) | - | 261 (21.3) |
| Other | 34 (10.8) | 41 (4.5) | - | 75 (6.1) |
| Smoking Score, mean (SD) | ||||
| Army STARRS | -5.4 (18.4) | -7.8 (18) | 4.75E-01 | -7.1 (18.1) |
| DNHS | 3.8 (30.5) | -0.6 (33) | 4.45E-01 | -0.3 (32.8) |
| GTP | -4.1 (35.4) | -2.8 (35.4) | 7.05E-01 | -3.3 (35.4) |
| MRS I&II | -8.5 (17) | -10.8 (15) | 4.43E-01 | -9.6 (16) |
| PRISMO | 1.3 (16.9) | 2 (21.3) | 9.06E-01 | 1.7 (19.7) |
| All | -4.1 (29.3) | -2.9 (31.3) | 5.21E-01 | -3.2 (30.8) |
| Childhood Trauma, mean (SD) | ||||
| Army STARRS | 7.1 (3.3) | 6.3 (2.2) | 1.44E-01 | 6.5 (2.5) |
| DNHS | 7.6 (5.7) | 4.4 (3.4) | 4.44E-03 | 4.7 (3.7) |
| GTP | 56.1 (20.1) | 37.7 (13.4) | 1.67E-21 | 43.8 (18.1) |
| MRS I&II | 41.7 (12.2) | 37.5 (10.4) | 4.10E-02 | 39.6 (11.5) |
| PRISMO | 5.5 (2.6) | 2.8 (2.2) | 1.03E-03 | 3.7 (2.7) |
| All | 39.1 (26.2) | 18.5 (18.5) | 3.3E-32 | 23.8 (22.6) |
| Cumulative Trauma, Mean (SD) | ||||
| Army STARRS | 1 (0) | 1 (0) | - | 1 (0) |
| DNHS | 12.2 (7) | 6.1 (4.1) | 3.63E-05 | 6.6 (4.7) |
| GTP | 7 (3.1) | 4.4 (2.8) | 2.33E-17 | 5.3 (3.1) |
| MRS I&II | 11.2 (2.9) | 10.3 (3.8) | 0.125 | 10.8 (3.4) |
| PRISMO | 6.5 (3.1) | 5.9 (3.8) | 0.557 | 6.1 (3.5) |
| All | 7.6 (4.8) | 5.2 (4) | 9.45E-15 | 5.8 (4.3) |