Table 1.
Characteristics of patients and PDAP outcomes according to susceptibility to Vancomycin
| Variable | Vancomycin sensitive (n = 96) | Vancomycin resistant (n = 66) | t/χ2/Z | P |
|---|---|---|---|---|
| Age | 61.9 ± 13.5 | 62.8 ± 14.3 | 0.408 | 0.684 |
| Sex (Male) | 44 (45.8) | 33 (50.0) | 0.272 | 0.602 |
| Primary disease | -0.023 | 0.982 | ||
| Chronic glomerulonephritis | 27 (28.1) | 22 (33.3) | ||
| Chronic interstitial nephritis | 5 (5.2) | 5 (7.6) | ||
| Diabetic nephropathy | 41 (42.7) | 19 (28.8) | ||
| Hypertensive nephropathy | 15 (15.6) | 7 (10.6) | ||
| Polycystic kidney disease | 2 (2.1) | 7 (10.6) | ||
| Immunity, tumor | 0 | 3 (4.5) | ||
| Other | 6 (6.3) | 3 (4.5) | ||
| Dialysis vintage (months) | 56.5 (25.3, 93.2) | 40.5 (21, 73.8) | -1.960 | 0.050 |
| Comorbidities | ||||
| Diabetes | 53 (55.2) | 22 (33.8) | 7.108 | 0.008 |
| Hypertension | 74 (77.1) | 48 (72.7) | 0.399 | 0.528 |
| Cardiovascular disease | 26 (27.1) | 15 (22.7) | 0.393 | 0.531 |
| Cerebrovascular disease | 16 (16.7) | 12 (18.2) | 0.063 | 0.802 |
| Dialysis effluent cell counts | ||||
| WBC (unit/µl) | 1454.5 (656.5, 3460.0) | 4543 (1500.0, 9286.5) | -4.393 | < 0.001 |
| PMNs (%) | 91.0 (86.0, 95.0) | 93.0 (87.7, 96.0) | -1.436 | 0.152 |
| Clinical manifestations | 18.670 | < 0.001 | ||
| PDAP-cloudy | 29 (96.7) | 1 (3.3) | ||
| PDAP-multi | 67 (50.8) | 65 (49.2) | ||
| Clinical biochemical indicators | ||||
| Hemoglobin (g/l) | 114.5 ± 14.4 | 111.4 ± 18.9 | -1.101 | 0.273 |
| Serum albumin (g/l) | 33.2 ± 5.2 | 33.0 ± 6.7 | -0.197 | 0.844 |
| Serum potassium (mmol/l) | 4.1 ± 0.7 | 3.9 ± 0.7 | -1.010 | 0.310 |
| CAPD treatment | 93(96.7%) | 62 (93.9%) | 0.815 | 0.444 |
| Kt/V total | 1.83 ± 0.30 | 1.90 ± 0.37 | 0.212 | |
| Kt/V residual | 0.11 ± 0.22 | 0.19 ± 0.29 | 0.070 | |
| Ccr total | 56.4 ± 8.54 | 59.2 ± 15.2 | 0.179 | |
| Residual Renal Ccr | 4.33 ± 8.54 | 8.96 ± 15.65 | 0.031 | |
| First episode peritonitis | 53(55.2%) | 21(31.8%) | 8.623 | 0.003 |
| Medical cure | 77(80.2%) | 33(50.0%) | 16.375 | < 0.001 |
| Recurrent peritonitis | 1(1.0%) | 1(1.5%) | 0.072 | 0.789 |
| Relapsing peritonitis | 10 (10.4%) | 5(7.6%) | 0.376 | 0.540 |
| Repeat peritonitis | 6 (6.3%) | 4(6.1%) | 0.002 | 0.961 |
| Peritonitis-associated hemodialysis transfer | 0 (0%) | 11(16.7%) | 17.166 | < 0.001 |
| Peritonitis-associated death | 2 (2.1%) | 12 (18.2%) | 12.838 | < 0.001 |
Abbreviation: PDAP, peritoneal dialysis-associated peritonitis; PMNs, polymorphonuclear neutrophils; WBC, white blood cell; Ccr, creatinine clearance