Table 2.
Top 10 highly enriched pathways from KEGG pathways enrichment analysis with ID, P-value, genes involved, and gene count.
| ID | Pathway Name | p-Value | GeneIDs | Count |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 5.3115 × 10−23 | PRKCG/PRKCA/PRKCB/PIK3CA/VEGFA/FGF2/BRAF/BCL2/BCL2L1/EGFR/IGF1R/KDR/MET/AXL/PIK3R1/SRC/AKT1/ERBB2/MAPK1/PIK3CB/STAT3/PDGFRB/AKT2/AKT3/MAP2K1/JAK2 | 26 |
| hsa04066 | HIF-1 signaling pathway | 2.17615 × 10−21 | EP300/EGLN1/PRKCG/PRKCA/PRKCB/PIK3CA/VEGFA/FLT1/NOS2/BCL2/PDK1/PFKFB3/EGFR/IGF1R/PIK3R1/AKT1/TLR4/ERBB2/MAPK1/PIK3CB/STAT3/INSR/TEK/GAPDH/HK1/AKT2/AKT3/MAP2K1 | 28 |
| hsa05205 | Proteoglycans in cancer | 2.29832 × 10−17 | PRKCG/PRKCA/PRKCB/PIK3CA/VEGFA/FGF2/HPSE/TNF/BRAF/CTNNB1/ESR1/MMP9/MMP2/EGFR/IGF1R/KDR/MET/PIK3R1/SRC/PTK2/AKT1/PTPN6/SHH/TLR4/ERBB2/MAPK1/PIK3CB/STAT3/MAPK14/AKT2/AKT3/MAP2K1 | 32 |
| hsa04151 | PI3K-Akt signalling pathway | 3.08738 × 10−17 | PRKCA/PIK3CA/PRKAA1/HSP90AA1/VEGFA/FGF1/FGF2/HSP90AB1/MCL1/FLT1/SGK1/CDK2/CDK4/HSP90B1/PIK3CG/BCL2/BCL2L1/CDK6/SYK/EGFR/IGF1R/KDR/MET/PIK3R1/PTK2/AKT1/TLR4/ERBB2/MAPK1/NGFR/PIK3CB/PDGFRB/FLT4/INSR/TEK/IL2/AKT2/AKT3/MAP2K1/JAK2/CSF1R | 41 |
| hsa04015 | Rap1 signaling pathway | 4.77529 × 10−17 | PRKCG/PRKCA/PRKCB/PIK3CA/VEGFA/FGF1/FGF2/FLT1/BRAF/CTNNB1/ADORA2A/EGFR/IGF1R/KDR/MET/PIK3R1/SRC/AKT1/DRD2/MAPK1/NGFR/PIK3CB/CNR1/PDGFRB/FLT4/INSR/TEK/MAPK14/AKT2/AKT3/MAP2K1/CSF1R | 32 |
| hsa05215 | Prostate cancer | 6.97404 × 10−17 | EP300/PIK3CA/HSP90AA1/HSP90AB1/MMP3/BRAF/CDK2/HSP90B1/BCL2/AR/CTNNB1/MMP9/EGFR/IGF1R/PIK3R1/AKT1/ERBB2/MAPK1/PIK3CB/PDGFRB/AKT2/AKT3/MAP2K1 | 23 |
| hsa04933 | AGE-RAGE signalling pathway in diabetic complications | 1.44583 × 10−16 | PRKCA/PRKCB/PIK3CA/NOX4/VEGFA/MAPK8/TNF/CDK4/BCL2/PRKCD/MMP2/PIK3R1/AKT1/MAPK1/PIK3CB/F3/STAT3/MAPK14/AKT2/AKT3/JAK2/TGFBR1/MAPK9 | 23 |
| hsa01522 | Endocrine resistance | 1.19061 × 10−15 | PIK3CA/MAPK8/BRAF/CDK4/BCL2/ESR1/MMP9/MMP2/EGFR/IGF1R/PIK3R1/SRC/PTK2/AKT1/ERBB2/MAPK1/PIK3CB/MAPK14/AKT2/AKT3/MAP2K1/MAPK9 | 22 |
| hsa05207 | Chemical carcinogenesis receptor activation | 4.00274 × 10−15 | PRKCG/PRKCA/PRKCB/PIK3CA/HSP90AA1/VEGFA/FGF2/HSP90AB1/CYP1B1/HSP90B1/BCL2/AR/CHRNA7/ESR1/AHR/EGFR/PIK3R1/SRC/AKT1/VDR/MAPK1/PIK3CB/CYP1A2/CYP3A4/STAT3/PPARA/AKT2/AKT3/MAP2K1/JAK2 | 30 |
| hsa05417 | Lipid and atherosclerosis | 5.91259 × 10−15 | PRKCA/PIK3CA/HSP90AA1/HSP90AB1/MMP1/MMP3/MAPK8/TNF/HSP90B1/BCL2/BCL2L1/MMP9/PIK3R1/SRC/PTK2/AKT1/TLR4/MAPK1/PIK3CB/CYP2C9/NFE2L2/STAT3/PPARG/HSPA8/HSPA5/MAPK14/AKT2/AKT3/JAK2/MAPK9 | 30 |