Table 2.

Synergistic mechanisms of AMPs and alkylating agents in cancer therapy.

Mechanism	Description	Reference
Membrane Disruption	AMPs disrupt cancer cell membranes, leading to cell lysis, facilitating the entry of alkylating agents.	[155]
DNA Damage	Alkylating agents cause DNA strand breaks, facilitated by AMPs.	[156]
Immune Modulation–Induction of Apoptosis	AMPs trigger apoptosis, which can be amplified by alkylating agents.	[157,158]
Anti-Angiogenesis	AMPs inhibit angiogenesis, which complements the cytotoxic effects of alkylating agents.	[159]
Overcoming Drug Resistance	AMPs reduce the potential for drug resistance to alkylating agents.	[160]