TABLE 3.
Nucleotide and amino acid sequence differences between VEEV subtype IC isolates
| Genomic nucleotide positiona | Protein geneb | Nucleotide (amino acid)e
|
||||||
|---|---|---|---|---|---|---|---|---|
| P676-gb (1963c) | V-198 (1962) | P676-ag (1963) | PMCHo5 (1964) | Panaquire (1983) | 6119 (1995) | 3908 (1995) | ||
| 422 | nsP1 | T | A | A | A | A | A | A |
| 476 | nsP1 | G | A | |||||
| 1247 | nsP1 | T | C | |||||
| 1442 | nsP1 | G | A | |||||
| 1571 | nsP1 | T | A | A | A | A | A | A |
| 2051 | nsP2 | C | T | T | T | T | T | T |
| 2579 | nsP2 | C | T | T | T | T | T | T |
| 2668d | nsP2 (339) | T (Val) | A (Glu) | A (Glu) | A (Glu) | A (Glu) | A (Glu) | A (Glu) |
| 2947d | nsP2 (432) | T (Ile) | C (Thr) | C (Thr) | C (Thr) | C (Thr) | C (Thr) | C (Thr) |
| 3407 | nsP2 | C | T | T | ||||
| 3941 | nsP2 | C | T | |||||
| 4049 | nsP3 | G | A | |||||
| 4100 | nsP3 | T | C | C | C | C | C | C |
| 4187 | nsP3 | A | G | G | G | G | G | G |
| 4213d | nsP3 (60) | C (Ala) | T (Val) | T (Val) | T (Val) | T (Val) | T (Val) | T (Val) |
| 4215d | nsP3 (61) | G (Ala) | A (Thr) | A (Thr) | A (Thr) | A (Thr) | A (Thr) | A (Thr) |
| 4226 | nsP3 | C | T | T | T | T | T | T |
| 4241 | nsP3 | A | G | G | G | G | G | G |
| 4244 | nsP3 | A | C | C | C | C | C | C |
| 4974 | nsP3 | C | T | |||||
| 5291 | nsP3 | T | C | |||||
| 5344d | nsP3 (437) | G (Gly) | A (Glu) | A (Glu) | A (Glu) | A (Glu) | A (Glu) | A (Glu) |
| 5350d | nsP3 (439) | T (Val) | C (Ala) | C (Ala) | ||||
| 5453 | nsP3 | G | A | |||||
| 5469d | nsP3 (479) | C (Pro) | T (Ser) | |||||
| 5474 | nsP3 | T | C | |||||
| 6182 | nsP4 | T | G | |||||
| 6497 | nsP4 | T | A | |||||
| 6663d | nsP4 (320) | G (Asp) | T (Tyr) | T (Tyr) | T (Tyr) | T (Tyr) | T (Tyr) | T (Tyr) |
| 7229 | nsP4 | C | T | T | ||||
| 7312d | nsP4 (536) | T (Val) | C (Ala) | |||||
| 9158d | E2 (199) | A (Lys) | G (Glu) | G (Glu) | G (Glu) | G (Glu) | G (Glu) | |
| 9622 | E2 (199) | T | C | |||||
| 10306 | E1 | G | A | |||||
| 10912 | E1 | C | T | |||||
a
Bold text denotes nucleotide differences that are not unique to the P676-gb sequence.
b
Numbers in parentheses refer to amino acid positions within each protein.
c
Year of isolation.
d
Encodes a deduced amino acid change.
e
Blank spaces indicate the same nucleotide as in strain P676-gb.